Common Painkillers May Cause "Heart attack risk"

According to the new study, there may be a link between taking high doses of common anti-inflammatory painkillers like ibuprofen and heart attacks. Over-the-counter common painkillers known as NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen are sold under brand names that includes Motrin or Advil, these are used to treat minor pains and aches, it also reduce fever.

People who take these medicine have a higher risk of heart attack or stroke, according to National Institutes of Health. http://www.nlm.nih.gov/medlineplus/druginfo/meds/a682159.html
The likelihood of experiencing a heart attack was calculated to increase by an average of 20% to 50%, compared with someone not taking the drugs, regardless of the dosage and amount of time  they are taken.

The findings are observational and based on an association, however, with the drugs not proved to be a a direct cause of heart attack.

This group of drugs includes ibuprofen, diclofenac, celecoxib and naproxen, which are available over the counter or by prescription for higher doses, to relieve pain or fever resulting from a range of causes that may include flu, headaches, back pain and menstrual cramps. Their range of uses also means they are often taken as needed, for short periods of time.

The level of risk increased as early as one week into the use of any drug in this category and at any dose, and the risk associated with taking higher doses was greatest within the first month. The overall findings suggest that people who take any dosage of these drugs for one week, one month or longer was linked to an increased risk of a heart attack. The risk appeared to decline when these painkillers were no longer taken, with a slight decline one to 30 days after use and a greater decline, falling below 11%, between 30 days and one year after use.

"We found that all common NSAIDs shared a heightened risk of heart attack," said Dr. Michèle Bally, an epidemiologist at the University of Montreal Hospital Research Center, who led the research. "There is a perception that naproxen has the lowest cardiovascular risk (among the NSAIDs), but that's not true."

Cardiovascular diseases are the No. 1 cause of death globally, according to the World Health Organization, with 80% of all deaths in this category due to heart attacks and strokes. Each year, it's estimated that 735,000 people in the United States have a heart attack. In the United Kingdom, more than 200,000 hospital visits each year are due to a heart attack.


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